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This report argues that real progress in health depends on strengthening health systems, centred on the principles of primary health care. This requires effective use of existing knowledge and technologies and innovation to create new health tools, along with appropriate structures and strategies to apply them. Success will need new forms of cooperation between international health agencies, national health leaders, health workers and communities, and other relevant sectors. Chapter 1 of the report looks at the current state of global health, highlighting the gap between the poor and better-off everywhere. Chapter 2 reflects on the slow progress towards achieving the Millenium Development Goals. Chapter 3 looks at the HIV/AIDS pandemic, and demonstrates why HIV/AIDS control needs to drive the agenda for the global health community. Chapter 4 looks at the steps needed to achieve polio eradication within the next few years, and chapter 5 concentrates on the lessons learned from the SARS outbreak. The theme of chapter 6 is the the overlap between communicable and non-communicable diseases and injuries occurring throughout the developing world, leading to a crisis of priorities for health systems. The concluding chapter returns to the statement that stronger health systems are necessary, and that strengthening health systems should be based on the principles and practices of primary health care