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This study describes the sexual behaviour of men and women in a fishing village on the shores of Lake Victoria in South West Uganda. The village is near a well known trading town truck stop on the main trans Africa highway with a high recorded prevalence of HIV infection. These data show a very high rate of sexual mixing within the village but little contact with people from outside. This suggests that all sexually active men and women in the village are at high risk of STDs including HIV. There is currently no formal health care available in the village. Such communities should be targeted in future STD control programmes