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This follow-up publication is intended to be read in conjunction with 'HIV/AIDS prevention and care for especially vulnerable young people: a framework for action', which set out five core principles underpinning effective HIV/AIDS prevention programming with young people: putting the young person first; promoting meaningful participation; a commitment to rights; promoting gender equity; and tackling risk and vulnerability. It outlines five case studies. Each case study describes how these principles have been put into action, through innovative approaches to working with young people who are homeless, using drugs, selling sex or living in deprived communities. Case studies come from Argentina, India, Iran, Kenya and Nigeria. This is a useful resource for policy-makers, practitioners and researchers working to promote young people's sexual health in resource-constrained settings